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The need for public health agencies to electronically exchange information with our stakeholders is growing, and the expectations for high levels of service require modernization of many of our information systems by making them integrated, interoperable, and standards-based. For public health to become an important player in health care reform, public health agencies will need to upgrade their systems in order to be an equal partner in health information exchange initiatives with the private health care sector (HITECH funding may support the development of this type of exchange). Conducting a readiness assessment for your organization can provide useful information for planning purposes, and can become a motivator for change within your organization. The Public Health Informatics Profile Toolkit is meant to serve as a guide that you can use to create a comprehensive summary of your agency´s current and projected information system needs and opportunities.