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This document serves as a guide for using YouTube and similar sites to disseminate products and engage with key audiences. The Division of eHealth Marketing (DeHM) will work with programs to tailor online video messages, track their download and use, and analyze the distribution of health videos. This document is designed to assist CDC programs both before they begin to develop content and concepts, as well as during dissemination and promotion of a video product. While DeHM is currently researching a number of video sites, the recommendations in this document are primarily for YouTube and may differ for other Web sites.