Each region of the United States experiences climate change and its impacts on health differently, due to the regions location-specific climate exposures and unique societal and demographic characteristics. The Centers for Disease Control and Prevention (CDC) Climate and Health Program supports states, counties, cities, tribes, and territories to assess how climate change will affect their community, identify vulnerable populations, and implement adaptation and preparedness strategies to reduce the health effects of climate change. This document describes the various health impacts climate change will have on different regions of the United States as outlined in the Fourth National Climate Assessment (NCA4), actions taken by the CDC Climate and Health Programs health department partners to prepare for and respond to climate change in their communities, and relevant tools and resources.