This guide offers a detailed introduction to biomonitoring and syndromic surveillance appropriate for local and state epidemiologists beginning a data collection or reporting project. Information and tools address elements of planning a biomonitoring project (including data collection procedures and working with inter-jurisdictional stakeholders), implementing the project (including data collection and analysis), and using data to inform public health response. The guide was developed by a CSTE occupational and environmental health subcommittee with significant input from state epidemiologists. This tool was identified through NACCHO's Resource Portfolio Project on the CDC Public Health Preparedness Capabilities. Through this project, NACCHO worked with the Center for Infectious Disease Research and Policy (CIDRAP) to identify, research, and validate tools, practices, and products that can assist LHDs to address challenges in meeting select PHEP capabilities.