This document outlines key topics, relevant resources, and current promising practices state and local MCM planners should consider when creating and implementing plans to transition emergency mass dispensing operations from the initial 10-day antibiotic distribution and dispensing effort to distributing and dispensing extended post-exposure prophylactic MCMs. This includes 50-day antibiotic supply, three shot vaccine series, and treatment supplies. The document covers a range of distribution and dispensing topics including maintaining essential functions, inventory management, tracking adverse events, and activation timelines. Note: This document is not meant to supplement, supersede, or replace any official federal MCM guidance, nor is it intended to act as official MCM guidance. This document is a compilation of observations from state and local subject matter experts using the most up-to-date information available at the time of document release. This document does not reflect the opinion or recommendations of the CDC or any of its employees. Persons using this document should verify any assumptions and concept of operations included in their own jurisdictional plans with local, state, and federal MCM representatives as part of the planning process. ASTHO and NACCHO do not promote or endorse any product or service mentioned in this document.