This Medication Center (Point of Dispensing / POD) Operations Manual describes how medication and/or vaccine will be dispensed to a large number of people, potentially everyone in Philadelphia, within 48 hours, in the event the population is exposed to a naturally occurring public health emergency or to a hazardous bioagent such as anthrax or smallpox. The POD Operations Manual describes the principles involved in mass dispensing operations, the organizational structure of the PDPH Command Center and the POD, and details how to set-up, open, run and close a POD. Supporting documentation, including job action sheets, forms, and a detailed list of POD supplies are located in the appendices. This manual is well developed to serve as a model for health departments preparing to enhance readiness for an emergency situation. It includes narrative of the training for staff in the Philadelphia area as well as example charts and forms that can be used as templates, information on different bioagents, information on different antibiotics, and pictures and diagrams of the POD.