Social media sites and other Web 2.0 technologies, such as Facebook, YouTube and Twitter, offer health communicators powerful new channels to deliver relevant and targeted health messages, often facilitated through trusted sources, when, where and how users want information. Since these technologies are newly emerging and are unfortunately prone to security vulnerabilities and attack vectors, mitigating these risks to protect the CDC network remains paramount to the Office of the Chief Information Security Officer (OCISO) and the programs alike. Risks associated with social media sites may be classified into two main realms: the risk associated with CDC content hosted on these sites (social media sites as systems); and risks to the CDC networks from staff using these sites for official or personal reasons (social media sites as vectors). This document focuses mainly on social media sites as vectors and mitigating the risks to the CDC network. However, some recommendations such as password policies, incident response plans, and security concerns such as malicious applications, overlap both realms.