The latest in NACCHO’s Syndemic Solutions in Action series come from Pima County, Oklahoma, and Chicago.

In its’ efforts to address syphilis, the Pima County Health Department (PCHD) in Arizona collaborated across health department divisions to create a new field-based, trauma-informed service delivery model. PCHD enhanced its traditional outreach efforts by deploying small interdisciplinary teams which operated out of a central van and tent to have regular contacts with individuals living in encampments. Read about how PCHD offered both clinical and non-clinical services to address the basic needs of the community through innovative approaches and regular, respectful engagement. Key lessons include the need for multidisciplinary, trauma-informed approaches, collaboration across the health department and with community partners, and a culture of innovation with leadership support. Click here to access the case study.

Learn how the Oklahoma State Department of Health (OKHD) worked to address an ongoing syphilis outbreak through partnerships with tribal organizations and community organizations working to reduce drug overdoses. OKHD and partners collaborated to align, prioritize, and maximize resources to test and treat syphilis, and support those who are most vulnerable to drug overdose in their communities. Click here to access the case study. 

The Chicago Department of Public Health (CDPH) used a syndemic approach to guide its 2025 mpox response. This case study describes how CDPH applied defined outbreak thresholds, activated an Incident Command System, strengthened case investigation and data use, and prioritized vaccination and outreach based on epidemiologic insights. Key lessons include the value of cross-team coordination, targeted provider engagement, venue-based outreach, and timely, adaptable communication to reach populations most affected by overlapping HIV, STI, and mpox risks. Click here to access the case study.